The "Difference of Squares" is a mathematical concept that refers to the expression formed by subtracting one square number from another. It can be represented as a² - b², where a and b are any real numbers. This expression can be factored into the product of two binomials: a² - b² = (a + b)(a - b). This property is useful in algebra for simplifying expressions and solving equations. It highlights the relationship between squares and their roots, making it easier to work with quadratic equations. Understanding the difference of squares can enhance problem-solving skills in mathematics.