Depolarizing neuromuscular blockers are a class of medications used to induce muscle relaxation during surgical procedures or mechanical ventilation. They work by binding to the acetylcholine receptors at the neuromuscular junction, causing an initial muscle contraction followed by paralysis. This effect is temporary and allows for easier intubation and surgical access. The most commonly used depolarizing neuromuscular blocker is succinylcholine. It is rapidly broken down by the enzyme plasma cholinesterase, leading to a short duration of action. While effective, these blockers can cause side effects, such as muscle pain and increased potassium levels, which need to be monitored during use.