A DataFrame is a two-dimensional, tabular data structure commonly used in data analysis and manipulation. It is part of the pandas library in Python and resembles a spreadsheet or SQL table, where data is organized in rows and columns. Each column can hold different data types, such as integers, floats, or strings, making it versatile for various data types. DataFrames allow for easy data handling, including filtering, grouping, and aggregating data. They provide built-in functions for statistical analysis and data visualization, making them essential for data scientists and analysts. The ability to read from and write to various file formats, like CSV and Excel, enhances their usability in data workflows.