A Data Frame is a two-dimensional, tabular data structure commonly used in programming languages like Python and R. It organizes data into rows and columns, where each column can hold different types of data, such as numbers, strings, or dates. This structure makes it easy to manipulate and analyze datasets, as it resembles a spreadsheet. Data Frames are particularly useful for data analysis and statistical modeling. They allow users to perform operations like filtering, grouping, and aggregating data efficiently. Libraries such as Pandas in Python and dplyr in R provide powerful tools for working with Data Frames, enhancing data handling capabilities.