A Data Frame is a two-dimensional, tabular data structure commonly used in programming languages like Python and R. It organizes data into rows and columns, where each column can hold different types of data, such as numbers, strings, or dates. This structure makes it easy to manipulate and analyze datasets, as it resembles a spreadsheet. Data Frames are particularly useful for data analysis tasks, allowing users to perform operations like filtering, grouping, and aggregating data. Libraries such as pandas in Python provide powerful tools for working with Data Frames, making data handling more efficient and intuitive.