DNA Damage Response
The DNA Damage Response (DDR) is a complex network of cellular processes that detect and repair damage to the DNA within cells. This damage can occur due to various factors, including environmental stress, radiation, and errors during DNA replication. The DDR ensures the integrity of the genetic material, preventing mutations that could lead to diseases such as cancer.
When DNA damage is detected, the DDR activates signaling pathways that halt the cell cycle, allowing time for repair mechanisms to fix the damage. If the damage is too severe, the DDR can trigger programmed cell death, or apoptosis, to eliminate potentially harmful cells. This protective response is crucial for maintaining overall cellular health and stability.