Cuyapaipe Creek is a small stream located in San Diego County, California. It is a tributary of the San Diego River and flows through the Cuyapaipe Indian Reservation, which is home to the Cuyapaipe Band of Diegueño Mission Indians. The creek is known for its natural beauty and diverse ecosystems. The creek's watershed supports various plant and animal species, making it an important habitat in the region. It also plays a role in local water management and conservation efforts. Cuyapaipe Creek is a vital resource for both the environment and the communities surrounding it.