The Crypts of Lieberkühn are small glandular structures located in the lining of the small intestine and colon. They are named after the German anatomist Johann Nathanael Lieberkühn, who described them in the 18th century. These crypts contain cells that produce intestinal juices and help in the absorption of nutrients. These crypts play a crucial role in maintaining the health of the intestinal lining. They house various cell types, including goblet cells, which secrete mucus, and Paneth cells, which produce antimicrobial substances. This helps protect the gut from pathogens and supports digestion.