Countess Isabella of Portugal (1503-1539) was a noblewoman from the House of Aviz. She was the daughter of King Manuel I of Portugal and Queen Maria of Aragon. Isabella married Charles V, Holy Roman Emperor, strengthening ties between Portugal and the Habsburg dynasty. Isabella played a significant role in the political landscape of her time. As the mother of Philip II of Spain, she influenced the future of European politics. Her life was marked by her dedication to her family and her involvement in the cultural and political affairs of the Spanish Empire.