Congenital Aganglionic Megacolon, also known as Hirschsprung's disease, is a condition present at birth where certain nerve cells are missing in the intestines. This absence of nerve cells, called ganglia, prevents normal bowel movements, leading to severe constipation and abdominal swelling. The condition primarily affects the large intestine, causing it to become enlarged, or megacolon. Diagnosis typically occurs in infancy, and treatment often involves surgery to remove the affected portion of the intestine. Early intervention is crucial for improving the child's quality of life and preventing complications.