The Confederacy of Independent Systems (CIS) was a coalition of various star systems and organizations that opposed the Galactic Republic during the Clone Wars. Formed in response to the increasing centralization of power in the Republic, the CIS sought to promote independence and autonomy for its member systems. It was primarily led by the Separatists, who were discontent with the Republic's governance. The CIS was supported by powerful corporations and influential figures, including Count Dooku and the Trade Federation. The organization utilized a vast droid army and various military assets to challenge the Republic's forces, significantly impacting the galaxy's political landscape during the conflict.