The Colombian drug trade refers to the production and distribution of illegal drugs, primarily cocaine, in Colombia. This trade has been a significant part of the country's economy since the late 20th century, with various criminal organizations, such as the Medellín Cartel and the Cali Cartel, playing key roles in its expansion. Efforts to combat the drug trade have included military interventions and anti-drug policies from both the Colombian government and international partners, particularly the United States. Despite these efforts, the trade remains a major challenge, contributing to violence and instability in the region.