Charles Best was a Canadian medical scientist best known for his role in the discovery of insulin. Born on February 27, 1899, in West Pembroke, Maine, he studied at the University of Toronto, where he later worked alongside Frederick Banting. Together, they conducted groundbreaking research that transformed the treatment of diabetes. In 1921, Best and Banting successfully isolated insulin from the pancreas of dogs, leading to its use in humans. This discovery significantly improved the lives of millions suffering from diabetes. For their contributions, Best and Banting received the Nobel Prize in Physiology or Medicine in 1923.