Charcot-Marie-Tooth disease (CMT) is a group of inherited disorders that affect the peripheral nerves, which are responsible for transmitting signals between the brain and muscles. This condition leads to muscle weakness, atrophy, and sensory loss, primarily in the feet and hands. Symptoms often begin in adolescence or early adulthood but can appear at any age. CMT is caused by genetic mutations that affect the structure and function of nerve cells. There are several types of CMT, each with different genetic causes and symptoms. While there is currently no cure, treatments focus on managing symptoms and improving quality of life through physical therapy and supportive devices.