Chafing is a skin irritation that occurs when skin rubs against skin or clothing, leading to redness, discomfort, and sometimes blisters. It commonly affects areas such as the thighs, underarms, and nipples, especially during physical activities like running or cycling. To prevent chafing, individuals can use lubricants, wear moisture-wicking fabrics, and ensure proper fitting of clothing. Staying dry and maintaining good hygiene can also help reduce the risk. If chafing occurs, applying soothing creams or ointments can aid in healing the affected skin.