Creutzfeldt-Jakob Disease (CJD) is a rare and fatal brain disorder caused by misfolded proteins called prions. These prions lead to the degeneration of brain tissue, resulting in severe neurological symptoms such as memory loss, personality changes, and difficulties with movement. CJD can occur in several forms, including sporadic, hereditary, and acquired. The disease typically affects older adults, with symptoms usually appearing around age 60. Diagnosis is challenging and often involves brain imaging and other tests. Unfortunately, there is currently no cure for CJD, and treatment focuses on alleviating symptoms and providing supportive care.