CDCs, or Centers for Disease Control and Prevention, are national public health institutions in the United States. Their primary role is to protect public health and safety by preventing and controlling disease, injury, and disability. They conduct research, provide health information, and respond to health emergencies. Established in 1946, CDCs focus on various health issues, including infectious diseases, chronic diseases, and environmental health. They also offer guidelines and recommendations for healthcare providers and the public to promote health and prevent illness. Their work is crucial in managing public health crises, such as outbreaks and pandemics.