The Bundle of His is a collection of heart tissue that plays a crucial role in the electrical conduction system of the heart. It is located in the interventricular septum and is responsible for transmitting electrical impulses from the atrioventricular (AV) node to the Purkinje fibers, which then stimulate the heart muscles to contract. This bundle is named after the German physician Wilhelm His Jr., who discovered it in the late 19th century. Proper functioning of the Bundle of His is essential for maintaining a coordinated heartbeat, and any disruptions can lead to various cardiac conditions, such as heart block.