The Buchwald-Hartwig Reaction is a chemical process used to form carbon-nitrogen bonds. It typically involves the coupling of an aryl or vinyl halide with an amine in the presence of a palladium catalyst. This reaction is valuable in organic synthesis for creating complex molecules, especially in pharmaceuticals and materials science. This reaction is named after chemists John Buchwald and Henry Hartwig, who developed the method in the late 1990s. It allows for the efficient formation of amines from readily available starting materials, making it a popular choice in synthetic organic chemistry.