The Negishi Reaction is a type of chemical reaction used in organic synthesis, where an organozinc compound reacts with an organic halide to form a new carbon-carbon bond. This reaction is named after Akira Negishi, who was awarded the Nobel Prize in Chemistry in 2010 for his contributions to the field. It is particularly useful for creating complex molecules in pharmaceuticals and materials science. In the Negishi Reaction, the organozinc reagent acts as a nucleophile, attacking the electrophilic carbon in the organic halide. This process allows for the formation of various carbon skeletons, making it a valuable tool for chemists. The reaction typically requires a palladium catalyst to facilitate the coupling process.