Brugia malayi is a parasitic worm that causes lymphatic filariasis, a disease affecting the lymphatic system. It is primarily transmitted to humans through the bites of infected mosquitoes, particularly those from the Anopheles and Aedes genera. The adult worms reside in the lymphatic vessels, leading to inflammation and swelling. Infection with Brugia malayi can result in severe symptoms, including lymphedema and hydrocele, which can significantly impact a person's quality of life. The disease is prevalent in tropical and subtropical regions, particularly in parts of Asia. Preventive measures include mosquito control and the use of medications to reduce transmission.