The Beta-3 receptor is a type of adrenergic receptor that primarily responds to the neurotransmitters norepinephrine and epinephrine. It is mainly found in adipose (fat) tissue and plays a crucial role in regulating energy metabolism and thermogenesis, which is the process of heat production in the body. Activation of the Beta-3 receptor can lead to increased lipolysis, the breakdown of fats, and improved insulin sensitivity. This receptor is of interest in research related to obesity and metabolic disorders, as targeting it may offer new therapeutic strategies for weight management and metabolic health.