Berberine is a natural compound found in several plants, including goldenseal, barberry, and Chinese goldthread. It has been used in traditional medicine for centuries, particularly in Chinese and Ayurvedic practices. Berberine is known for its potential health benefits, including supporting metabolic health and regulating blood sugar levels. Research suggests that berberine may help improve insulin sensitivity and reduce cholesterol levels. It works by activating an enzyme called AMP-activated protein kinase (AMPK), which plays a crucial role in energy metabolism. While promising, more studies are needed to fully understand its effects and optimal usage.