BRAF V600E is a specific mutation in the BRAF gene, which plays a crucial role in cell signaling pathways that control cell growth and division. This mutation results in a change in the amino acid sequence of the protein, leading to uncontrolled cell proliferation. It is commonly associated with various types of cancer, particularly melanoma. The presence of the BRAF V600E mutation can influence treatment decisions, as targeted therapies, such as BRAF inhibitors, have been developed to specifically address cancers with this mutation. Testing for BRAF V600E is often performed to guide personalized treatment strategies for patients.