B-cell development occurs primarily in the bone marrow, where precursor cells undergo several stages of maturation. These cells rearrange their DNA to produce unique B-cell receptors (BCRs), which are essential for recognizing specific antigens. Successful BCR formation leads to further maturation and selection processes to ensure that the B-cells can effectively respond to pathogens. Once matured, B-cells migrate to peripheral lymphoid organs, such as the spleen and lymph nodes. Here, they encounter antigens and can differentiate into plasma cells that produce antibodies or memory B-cells that provide long-term immunity. This development is crucial for the adaptive immune response.