Azide-Alkyne Cycloaddition is a chemical reaction that combines an azide and an alkyne to form a triazole compound. This reaction is significant in organic chemistry due to its efficiency and selectivity, allowing for the formation of complex molecules with minimal byproducts. It typically occurs under mild conditions, making it suitable for various applications. This reaction is a key component of click chemistry, a term coined by K. Barry Sharpless to describe reactions that are simple, reliable, and produce high yields. The versatility of azide-alkyne cycloaddition has made it popular in fields such as bioconjugation and drug development.