An Application Framework is a set of tools and libraries that help developers build software applications more efficiently. It provides a structured foundation, allowing programmers to focus on creating unique features instead of starting from scratch. By using an application framework, developers can save time and reduce errors, as many common tasks are already handled by the framework. Popular examples of application frameworks include Django for web development in Python and Ruby on Rails for building web applications in Ruby. These frameworks offer pre-built components and guidelines, making it easier for developers to create robust and scalable applications while maintaining best practices.