Alpha-2 receptors are a type of adrenergic receptor found in the body that primarily respond to the neurotransmitters norepinephrine and epinephrine. They play a crucial role in regulating various physiological processes, including blood pressure, sedation, and pain modulation. When activated, these receptors inhibit the release of further norepinephrine, creating a feedback mechanism that helps control the sympathetic nervous system's activity. These receptors are located in both the central and peripheral nervous systems. In the brain, they help regulate mood and anxiety, while in the peripheral tissues, they can influence blood vessel constriction and insulin release. Medications that target alpha-2 receptors are often used to treat conditions like hypertension and ADHD.