Aldolase A is an enzyme that plays a crucial role in the glycolysis pathway, which is the process that breaks down glucose to produce energy. It specifically catalyzes the conversion of fructose 1,6-bisphosphate into glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. This reaction is essential for energy production in cells. Aldolase A is primarily found in muscle and brain tissues, where energy demand is high. It is one of three isoforms of aldolase, with the others being Aldolase B and Aldolase C. Mutations in the gene encoding Aldolase A can lead to metabolic disorders, affecting energy metabolism.