Thick filaments are essential components of muscle fibers, primarily composed of the protein myosin. They play a crucial role in muscle contraction by interacting with thin filaments, which are mainly made of actin. The structure of thick filaments allows them to form cross-bridges with thin filaments, facilitating the sliding mechanism that leads to muscle shortening and force generation. In addition to their role in muscle contraction, thick filaments are also involved in maintaining the structural integrity of muscle cells. They are organized in a specific arrangement within the sarcomere, the basic unit of muscle tissue, ensuring efficient contraction and relaxation during physical activity.