Tangles refer to a state where items, such as strings, wires, or hair, become intertwined or knotted together, making them difficult to separate. This can happen due to movement, storage, or improper handling. Tangles can occur in various contexts, including everyday life, crafts, and technology. In the context of neuroscience, tangles can also describe a specific type of abnormal structure found in the brains of individuals with Alzheimer's disease. These tangles are formed by the accumulation of a protein called tau, which disrupts normal cell function and contributes to cognitive decline.