A systemic disease is a condition that affects multiple organs or systems in the body rather than being localized to a single area. These diseases can disrupt normal bodily functions and may involve the immune system, circulatory system, or other vital systems. Examples include lupus, diabetes, and rheumatoid arthritis. Systemic diseases often present a range of symptoms that can vary widely among individuals. Diagnosis typically requires a comprehensive evaluation, including blood tests and imaging studies, to assess the overall health of the body. Early detection and management are crucial for improving outcomes and maintaining quality of life.