Succinate dehydrogenase is an enzyme found in the mitochondria of cells. It plays a crucial role in the Krebs cycle, which is essential for energy production. This enzyme catalyzes the conversion of succinate to fumarate, facilitating the transfer of electrons to the electron transport chain. In addition to its role in metabolism, succinate dehydrogenase is unique because it is the only enzyme that participates in both the Krebs cycle and the electron transport chain. It contains several important cofactors, including FAD, which help in the oxidation-reduction reactions necessary for energy generation.