solid-phase peptide synthesis
Solid-phase peptide synthesis (SPPS) is a method used to create peptides by attaching amino acids to a solid support. This technique allows for the sequential addition of amino acids, which are linked together to form a peptide chain. The solid support simplifies purification and makes it easier to manage the reaction process.
In SPPS, the first amino acid is anchored to a resin, and subsequent amino acids are added one at a time. After each addition, the unreacted sites are washed away, ensuring that only the desired peptide is formed. This method is widely used in biochemistry and pharmaceutical research for producing peptides efficiently.