Secondary immunodeficiency disorders occur when the immune system is weakened due to external factors, rather than being inherited. These factors can include infections, such as HIV, certain medications like corticosteroids, or chronic diseases such as diabetes and cancer. As a result, the body becomes more susceptible to infections and illnesses. Unlike primary immunodeficiency disorders, which are genetic, secondary immunodeficiencies can develop at any age. Treatment often focuses on managing the underlying cause, such as controlling HIV or adjusting medications. In some cases, patients may require additional therapies to help boost their immune response.