Retinoic acid receptor alpha (RARA) is a protein that plays a crucial role in regulating gene expression in response to retinoic acid, a derivative of vitamin A. RARA is part of a larger family of nuclear receptors that influence various biological processes, including cell growth, differentiation, and development. It binds to specific DNA sequences to activate or repress target genes, thereby impacting cellular functions. RARA is particularly important in the context of certain diseases, such as acute promyelocytic leukemia (APL), where mutations in the RARA gene can disrupt normal cellular processes. Understanding RARA's function helps researchers develop targeted therapies that can restore normal gene regulation and improve treatment outcomes for patients with APL and other related conditions.