Nuclear reprogramming is a scientific process that involves altering the genetic material of a cell to revert it to a more primitive, stem cell-like state. This technique allows researchers to transform specialized cells, such as skin cells, into pluripotent stem cells, which can develop into various cell types. This process is significant in regenerative medicine and research, as it opens up possibilities for creating tissues and organs for transplantation. One well-known method of nuclear reprogramming is the use of induced pluripotent stem cells (iPSCs), which were first developed by Shinya Yamanaka in 2006.