The neurokinin-2 receptor (NK2R) is a protein found in the body that belongs to the family of G-protein coupled receptors. It primarily binds to neurokinin A, a neuropeptide involved in various physiological processes, including pain perception, inflammation, and smooth muscle contraction. NK2R is mainly expressed in the central nervous system and peripheral tissues, playing a crucial role in regulating functions such as respiratory and gastrointestinal activities. Research on the neurokinin-2 receptor has implications for understanding and treating conditions like asthma, anxiety, and gastrointestinal disorders. By targeting NK2R, scientists aim to develop new therapies that can modulate its activity, potentially leading to improved management of these health issues.