Misfolding refers to the incorrect folding of proteins, which are essential molecules in living organisms. Proteins need to fold into specific shapes to function properly. When they misfold, they can lose their ability to perform their intended tasks, leading to various health issues. This phenomenon is often associated with diseases such as Alzheimer's disease and Parkinson's disease, where misfolded proteins accumulate and form harmful aggregates. These aggregates can disrupt cellular functions and contribute to the progression of these conditions, highlighting the importance of proper protein folding in maintaining health.