Leukodystrophy is a group of rare genetic disorders that affect the white matter of the brain. This white matter is crucial for transmitting signals between nerve cells, and its damage can lead to various neurological problems. Symptoms may include developmental delays, muscle weakness, and difficulties with coordination and speech. The condition is caused by mutations in genes responsible for the production and maintenance of myelin, the protective sheath surrounding nerve fibers. There are several types of leukodystrophy, including Krabbe disease, Adrenoleukodystrophy, and Metachromatic leukodystrophy, each with different symptoms and progression rates.