inducible nitric oxide synthase
Inducible nitric oxide synthase (iNOS) is an enzyme responsible for producing nitric oxide (NO) in response to inflammatory signals. Unlike other forms of nitric oxide synthase, iNOS is not constantly present in cells but is induced during immune responses, particularly in macrophages and endothelial cells. This production of NO plays a crucial role in the body's defense against pathogens and in regulating blood flow.
The nitric oxide generated by iNOS has various biological effects, including antimicrobial activity and modulation of inflammation. However, excessive production of NO can lead to tissue damage and contribute to various diseases, such as sepsis and autoimmune disorders. Understanding iNOS is important for developing therapies targeting inflammatory conditions.