The main difference between iPhone and Android lies in their operating systems. iPhone runs on iOS, which is exclusive to Apple devices, while Android is an open-source platform used by various manufacturers like Samsung, Google, and OnePlus. This leads to a wider variety of Android devices with different features, sizes, and price points. Another key distinction is the app ecosystem. iOS typically offers a more curated selection of apps, often prioritizing quality and security. In contrast, the Android platform provides greater flexibility, allowing users to customize their devices and access a broader range of applications, including those from third-party sources.