Fibrinolysis is the biological process that breaks down fibrin, a protein involved in blood clotting. This process is essential for maintaining normal blood flow after a clot has formed to stop bleeding. Enzymes, primarily plasmin, play a key role in dissolving the fibrin mesh that stabilizes the clot, allowing for tissue repair and restoration of circulation. The fibrinolytic system is tightly regulated to ensure that clots dissolve at the right time. Plasminogen, an inactive precursor of plasmin, is converted into active plasmin by tissue plasminogen activator (tPA) and other factors. This balance prevents excessive bleeding or unwanted clot formation, which can lead to conditions like thrombosis.