Equine leukoencephalomalacia is a neurological condition that affects horses, primarily caused by the ingestion of moldy corn containing toxins produced by the fungus Fusarium verticillioides. This disease leads to the softening of brain tissue, resulting in various neurological symptoms such as incoordination, seizures, and behavioral changes. Diagnosis is typically made through clinical signs and may be confirmed with a post-mortem examination. Treatment options are limited, and prevention focuses on proper storage of feed to avoid mold growth. Early detection is crucial for managing the condition and improving outcomes for affected horses.