The epidermal barrier is the outermost layer of the skin, primarily composed of keratinocytes, which are specialized skin cells. This barrier plays a crucial role in protecting the body from environmental factors, such as bacteria, pollutants, and harmful chemicals. It also helps to prevent excessive water loss, maintaining skin hydration and overall health. The epidermal barrier is made up of several components, including lipids and proteins, that work together to create a strong, flexible shield. When this barrier is compromised, it can lead to skin issues like dryness, irritation, and increased susceptibility to infections. Maintaining the integrity of the epidermal barrier is essential for healthy skin.