Degenerative changes refer to the gradual deterioration of tissues or organs in the body, often due to aging or chronic stress. These changes can affect various systems, including the musculoskeletal system, leading to conditions like arthritis, where cartilage breaks down, causing pain and reduced mobility. These changes can also occur in the nervous system, resulting in disorders such as Alzheimer's disease, which affects memory and cognitive function. While degenerative changes are a natural part of aging, they can be influenced by factors like genetics, lifestyle, and environmental conditions, impacting overall health and quality of life.