Alpha-2 receptors are a type of adrenergic receptor found in the body that primarily respond to the neurotransmitters norepinephrine and epinephrine. They are part of the sympathetic nervous system and play a crucial role in regulating various physiological processes, including blood pressure and heart rate. When activated, these receptors can inhibit the release of further neurotransmitters, leading to a calming effect on the nervous system. These receptors are located in several areas, including the brain, blood vessels, and pancreas. Their activation can lead to decreased sympathetic outflow, which helps lower blood pressure and reduce anxiety. Medications that target alpha-2 receptors, such as clonidine, are often used to treat conditions like hypertension and attention deficit hyperactivity disorder (ADHD).