Adrenal gland disease refers to disorders affecting the adrenal glands, which are small glands located on top of each kidney. These glands produce hormones that regulate various bodily functions, including metabolism, immune response, and stress management. Common conditions include Cushing's syndrome, characterized by excessive cortisol production, and Addison's disease, where the glands do not produce enough hormones. Symptoms of adrenal gland disease can vary widely, including fatigue, weight changes, and mood swings. Diagnosis typically involves blood tests, imaging studies, and hormone level assessments. Treatment options may include medication, lifestyle changes, or surgery, depending on the specific condition and its severity.