The "Ya-Ya Sisterhood" refers to a fictional group of lifelong friends from the novel "Divine Secrets of the Ya-Ya Sisterhood" by Rebecca Wells. The story explores themes of friendship, family, and the complexities of women's relationships through the lives of the Ya-Ya sisters, who support each other through various challenges. The novel, published in 1996, became popular for its portrayal of Southern culture and the bond between women. It was later adapted into a film in 2002, further expanding its reach and influence. The Ya-Ya Sisterhood symbolizes the strength and resilience found in female friendships.