Whipple's Disease is a rare bacterial infection caused by the organism Tropheryma whipplei. It primarily affects the gastrointestinal system, leading to symptoms such as abdominal pain, diarrhea, and weight loss. The disease can also impact other organs, including the heart, lungs, and nervous system, making it a systemic condition. Diagnosis often involves a biopsy of affected tissue, where the bacteria can be identified. Treatment typically includes long-term antibiotics to eliminate the infection. If left untreated, Whipple's Disease can lead to serious complications, but early intervention can improve outcomes significantly.